• br DNA damage and response DDR DNA in

  2019-04-25

  

  DNA damage and response (DDR) DNA in cells of living organisms is continuously exposed to devastating factors present endogenously and exogenously which can introduce DNA damage thereby resulting in loss of genome integrity [30]. Genome integrity is affected by DNA replication errors, endogenous

• br Acknowledgments This work was supported by grants from th

  2019-04-25

  

  Acknowledgments This work was supported by grants from the National Science Council (project number: MOST-103-2320-B-040-004 and NSC 102-2313-B-002 -039 -MY3). The authors would like to thank Dr. Bernard A. Schwetz for carefully reading the manuscript and helpful discussions which improved the ar

• Therefore other imaging techniques and tools have been

  2019-04-25

  

  Therefore, other imaging techniques and tools have been evaluated. The results of this study add to the body of evidence demonstrating the value of SPECT and the need for a multifactorial approach to patient selection for CRT and in evaluating potential predictors of CRT response in non-ischemic pat

• br Discussion The implant of a CRT

  2019-04-25

  

  Discussion The implant of a CRT device in a patient with a resting ejection fraction of 50% represents off-guideline use of this therapy [1]. However, since the patient׳s significant NYHA Class III symptoms, LBBB and exertional ventricular dysfunction achieved evidence-based levels for improvemen

• Sultan et al retrospectively searched the surveillance

  2019-04-25

  

  Sultan et al retrospectively searched the surveillance, epidemiology, and end results (SEER) database for patients who were diagnosed with NPC from 1988 to 2006. They compared the clinical features and outcomes of 129 children and adolescents (n and young adults compared with older adults with nasop

• br Conclusion br Conflict of

  2019-04-25

  

  Conclusion Conflict of interest Introduction Future challenges and conclusion In recent decades several anticancer drugs have been approved for the management and treatment of colorectal cancer. These drugs do not represent a revolution in the treatment of CRC. However, 5-FU has continue

• br Case report Radiographs showed a lytic lesion in

  2019-04-25

  

  Case report Radiographs showed a lytic lesion in the left ilium adjacent to the sacroiliac joint (Fig. 1). Computed tomography (CT) (Fig. 2) showed a 5.5×5.0×3.4cm3 lytic lesion in the left ilium; the sacrum was not involved. The lesion was of uniform density with no bone or cartilage matrix form

• br Discussion The rate of ERP

  2019-04-25

  

  Discussion The rate of ERP in young, healthy men in northeastern Thailand was 10.3%. This is higher than the rate reported in the US (3.3–6.1%) [12]. In the US report, the mean age of the study population was 45 years, which was older than the age of subjects in our study. Another report from the

• Cerrone et al reported that the mechanism of CPVT

  2019-04-25

  

  Cerrone et al. reported that the mechanism of CPVT was due to delayed afterdepolarization‐induced triggered activity in a focal Purkinje network in a knock-in (RyR2) mouse [36]. In addition, chemical ablation of the RV endocardial cavity with Lugol׳s solution, which selectively destroys the Purkinje

• In silico prediction software SIFT PolyPhen CADD and

  2019-04-25

  

  In silico prediction software, SIFT [51], PolyPhen2 [52], CADD [53], and other prediction systems are useful to evaluate a specific mutation which is detected in a patient. However, even if the in silico software predicts a mutation as pathogenic, we need to examine whether the genetic result is com

• More recently Brugada et al used flecainide to identify the

  2019-04-25

  

  More recently, Brugada et al. [131]. used flecainide to identify the full extent of low-voltage electrogram activity in the anterior RV and RVOT and targeted this region for RFA. In all 14 BrS patients, RFA eliminated abnormal bipolar electrograms, normalized ST-segment elevation on right precordial

• Paisey et al recently proposed

  2019-04-24

  

  Paisey et al. recently proposed a simple technique for recognizing an MI block. In their study, an abrupt change of the CS activation pattern during RF application, under left atrial appendage pacing from a distal-to-proximal to proximal-to-distal direction provided a reliable assessment of MI condu

• In patients with surgically corrected CHD the anatomic posit

  2019-04-24

  

  In patients with surgically corrected CHD, the anatomic position of the atriotomy scar as the arrhythmogenic substrate is commonly found in the free wall and not in the septum [8]. The cause of this large area of low voltage (“atrial myopathy”) is unclear. Possible explanations include interruption

• Nademanee et al reported nine symptomatic

  2019-04-24

  

  Nademanee et al. reported nine symptomatic patients with BrS who experienced VF and underwent electrophysiological study and catheter ablation [8]. The patients exhibited abnormal epicardial electrograms characterized by fragmented electrograms with a relatively low voltage ( Idiopathic ventricular

• The investigators suggest use of doxycycline which is effect

  2019-04-24

  

  The investigators suggest use of doxycycline, which is effective for both diseases, as a possible empirical treatment at the primary level of care. Because the consequences of an untreated true case of rickettsiosis or leptospirosis are much greater than are those of unnecessary treatment, Mayxay an

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